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During concomitant use of INDOCIN and ACE-inhibitors.ARBs.or beta-blockers.monitor blood pressure to ensure that the desired blood pressure is obtained. During concomitant use of INDOCIN and ACE-inhibitors or ARBs in patients who are elderly.volume-depleted.or have impaired renal function.monitor for signs of worsening renal function [see WARNINGS AND PRECAUTIONS ]. When these drugs are administered concomitantly.patients should be adequately hydrated. Assess renal function at the beginning of the concomitant treatment and periodically thereafter.
Some drugs may affect the way indomethacin works.and indomethacin may affect other drugs you are taking.
A subpopulation of patients with asthma may have aspirin-sensitive asthma which may include chronic rhinosinusitis complicated by nasal polyps. severe.potentially fatal bronchospasm. and/or intolerance to aspirin and other NSAIDs. Because cross-reactivity between aspirin and other NSAIDs has been reported in such aspirin-sensitive patients.INDOCIN is contraindicated in patients with this form of aspirin sensitivity [see CONTRAINDICATIONS ]. When INDOCIN is used in patients with preexisting asthma (without known aspirin sensitivity).monitor patients for changes in the signs and symptoms of asthma.
As advancing years appear to increase the possibility of adverse reactions.INDOCIN should be used with greater care in the elderly [see Use In Specific Populations ].
INDOCIN affords relief of symptoms. it does not alter the progressive course of the underlying disease.
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