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Information about Colchicine.
Because colchicine is a substrate for both the CYP3A4 metabolizing enzyme and the P-glycoprotein efflux transporter.inhibition of either of these pathways may lead to colchicine-related toxicity. Inhibition of both CYP3A4 and P-gp by dual inhibitors such as clarithromycin has been reported to produce life-threatening or fatal colchicine toxicity due to significant increases in systemic colchicine levels. Therefore.concomitant use of colchicine capsules and inhibitors of CYP3A4 or P-glycoprotein should be avoided [See DRUG INTERACTIONS ]. If avoidance is not possible.reduced daily dose should be considered and the patient should be monitored closely for colchicine toxicity. Use of colchicine capsules in conjunction with drugs that inhibit both P-gp and CYP3A4 is contraindicated in patients with renal or hepatic impairment [See CONTRAINDICATIONS ].
You shouldn’t eat grapefruit or drink grapefruit juice while taking colchicine. Talk to your doctor about this potential interaction.
Colchicine induced myotoxicity may occur in presence of normal renal function.
Physicians should ensure that patients are suitable candidates for treatment with colchicine capsules and remain alert for signs and symptoms of toxic reactions associated with increased colchicine exposure due to drug interactions. Signs and symptoms of colchicine toxicity should be evaluated promptly and.if toxicity is buy colchicine from canada.colchicine capsules should be discontinued immediately.
Gout is rare in pediatric patients. the safety and effectiveness of colchicine capsules in pediatric patients has not been evaluated in controlled studies.
Blood dyscrasias (eg.leukopenia.myelosuppression.thrombocytopenia.pancytopenia.granulocytopenia.aplastic anemia) have been reported at therapeutic dosages.
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