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Because of the potential for serious adverse reactions in nursing infants from ponstel, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.

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Mefenamic acid may also cause stomach or intestinal bleeding.which can be fatal. These conditions can occur without warning while you are using mefenamic acid.especially in older adults.

heart disease.high blood pressure.high cholesterol.diabetes.or if you smoke. a history of heart attack.stroke.or blood clot. a history of stomach ulcers or bleeding. asthma. fluid retention. or liver disease.

signs of stomach bleeding–bloody or tarry stools.coughing up blood or vomit that looks like coffee grounds.

If you take Ponstel (mefenamic acid) on a regular basis.take a missed dose as soon as you think about it. If it is close to the time for your next dose.skip the missed dose and go back to your normal time. Do not take 2 doses at the same time or extra doses. Many times Ponstel (mefenamic acid) is taken on an as needed basis. Do not take more often than told by the doctor.

There is no consistent evidence that concurrent use of aspirin mitigates the increased risk of serious CV thrombotic events associated with NSAID use. The concurrent use of aspirin and an NSAID.such as mefenamic acid.increases the risk of serious gastrointestinal (GI) events ( see WARNINGS. Gastrointestinal Bleeding.Ulceration.and Perforation ).

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ponstel mefenamic acid is in a group of drugs called nonsteroidal anti-inflammatory drugs nsaids .